When it comes to juvenile diabetes research, there is so much to talk about it could not all be written here. In an effort to bring some of the more current information, here is the following.
Juvenile diabetes, commonly referred to as type I diabetes, since it is most common in juveniles, is an autoimmune disease. An autoimmune disease is one that sees its’ own cells and tissue as the enemy and launches an all out attack on them. In the case of type I diabetes, the focus of the attack is the beta producing cells of the pancreas. Although it is still not known why this happens, researchers are always studying in an effort to learn and progress is being made, albeit slow. One such juvenile diabetes research scientist recently did a study of mice and identified certain signals that underscore tolerance in beta cells and help prevent diabetes. This scientist also tested a new treatment and found it effective in preventing the disease. In each case these findings could lead to new immune therapies.
Before this study got underway, there had already been previous research that showed a specific immune cell protein that had a key role in making beta cell tolerant. What wasn’t known was the pathway it took. One group of mice were injected with immune cells that caused them to get diabetes. Then the researchers took a part of that group and gave them an antigen specific treatment that directly targeted specific immune cells instead of the entire immune system, the remainder of the mice were given a dummy treatment. The antigen specific treatment worked. These mice did not develop diabetes, while the mice in the other group developed diabetes within six days. This indicated that the treatment blocked the signal making the injected immune cells tolerant of beta cells and therefore preventing diabetes.
The key point here, with regard to juvenile diabetes research and its’ development, is that science is understanding how tolerance works. It is possible that it could lead to treatments that could halt the autoimmune process that is the cause of type I diabetes. They are learning that two proteins talking to one another can block the immune cell signal and in the study, protect the mice from diabetes. Just to prove their test, the researchers blocked the conversation and diabetes did develop. This research uncovered important clues and confirmed that this type of treatment is among the most promising for type I diabetes and can prevent diabetes.
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Juvenile diabetes, commonly referred to as type I diabetes, since it is most common in juveniles, is an autoimmune disease. […….
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